Patients with rheumatoid arthritis (RA) are treated with drugs that may impact their immune responses to SARS-CoV-2 vaccines. We describe here the anti-Spike (anti-S) IgG and neutralizing antibody responses induced by the mRNA-1273 SARS-CoV-2 vaccine in a 78-years-old patient with RA, who received a low-dose combination therapy of methotrexate and adalimumab, shortly before vaccine administration. Both near-normal and impaired immune responses to vaccines have been reported previously in patients treated with these drugs. Our case report shows that, even at low doses, combined methotrexate-adalimumab therapy can be associated with a weak immune response to the mRNA1273 vaccine in elderly patients.
All Keywords
【저자키워드】 SARS-CoV-2, Antibody Response, methotrexate, adalimumab, mRNA1273 vaccine, 【초록키워드】 IgG, Vaccine, immune response, therapy, mRNA-1273, drugs, combination therapy, SARS-CoV-2 vaccines, drug, elderly patients, rheumatoid arthritis, SARS-CoV-2 vaccine, Case report, mRNA1273, low-dose, Patient, Neutralizing antibody response, doses, anti-S, vaccine administration, reported, treated, patients treated, 【제목키워드】 mRNA-1273, elderly, response, Impact, Rheumatoid, induced,
【저자키워드】 SARS-CoV-2, Antibody Response, methotrexate, adalimumab, mRNA1273 vaccine, 【초록키워드】 IgG, Vaccine, immune response, therapy, mRNA-1273, drugs, combination therapy, SARS-CoV-2 vaccines, drug, elderly patients, rheumatoid arthritis, SARS-CoV-2 vaccine, Case report, mRNA1273, low-dose, Patient, Neutralizing antibody response, doses, anti-S, vaccine administration, reported, treated, patients treated, 【제목키워드】 mRNA-1273, elderly, response, Impact, Rheumatoid, induced,