Patients with COVID-19 show a high prevalence of liver injury. The pattern of this liver damage is still not fully understood. Different etiopathogenetic factors may concur; from a direct cytopathic effect, once the virus binds to the ACE-2 receptors, to the immune-mediated collateral damage, due to cytokine storm. The presence of pre-existing chronic liver disease is a contributing factor for acute organ damage during SARS-CoV2 infection. Last but not least, treatments probably play a role, also, in determining hepatotoxicity: many of the drugs we have used or are still using to treat COVID-19, combined with non-invasive ventilation, are known to sometimes determine acute liver injury. Although liver damage associated with COVID-19 is often transient and can resolve without any special treatment, it is important to understand the underlying mechanisms, particularly to better treat its more severe forms.
【저자키워드】 COVID-19, SARS-CoV2, drugs, liver, Injury, NIV, 【초록키워드】 Treatment, Cytokine storm, drug, virus, SARS-CoV2 infection, ACE-2, Prevalence, Liver injury, non-invasive ventilation, mechanisms, receptors, Immune-mediated, Liver damage, Cytopathic effect, chronic liver disease, Factor, Acute liver injury, treat, organ damage, forms, bind, determine, Last, with COVID-19, 【제목키워드】 role,