To successfully protect against pathogen infection, a vaccine must elicit efficient adaptive immunity, including B and T cell responses. While B cell responses are key, as they can mediate antibody-dependent protection, T cells can modulate B cell activity and directly contribute to the elimination of pathogen-infected cells. In the unprecedented race to develop an effective vaccine for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the respiratory disease coronavirus disease 2019 (COVID-19), messenger RNA (mRNA) vaccines have emerged as front runners thanks to their capacity for rapid development and ability to drive potent adaptive immune responses. In this review article, we provide an overview of the results from pre-clinical studies in animal models as well as clinical studies in humans that assessed the efficacy of SARS-CoV-2 mRNA vaccines, with a primary focus on adaptive immune responses post vaccination.
【저자키워드】 antibodies, SARS-CoV-2, Adaptive immunity, coronavirus, memory B cells, mRNA vaccines, germinal centers, T follicular helper cells, long-lived plasma cells, Th1 cells, 【초록키워드】 COVID-19, coronavirus disease, Efficacy, Vaccine, adaptive, Immunity, Human, Infection, animal model, B cell, T cell, pathogen, cells, mRNA, T cell responses, Respiratory disease, Adaptive immune response, clinical study, adaptive immune responses, B cell response, Messenger RNA, acute respiratory syndrome, post vaccination, while, effective, PROTECT, develop, contribute, modulate, elicit, 【제목키워드】 mRNA,