The aim of this study was to assess adverse reactions to COVID-19 vaccines, comparing the BNT162b2 or the mRNA-1273 COVID-19 vaccines and the presence and seriousness of a previous COVID-19 infection. We conducted a cross-sectional online survey of vaccinated healthcare workers at a tertiary hospital in Barcelona (Spain). Thirty-eight percent of vaccine recipients responded to the questionnaire. We compared the prevalence of adverse reactions by vaccine type and history of COVID-19 infections. A total of 2373 respondents had received the BNT162b2 vaccine, and 506 the mRNA-1273 vaccine. The prevalence of at least one adverse reaction with doses 1 and 2 was 41% and 70%, respectively, in the BNT162b2 group, and 60% and 92% in the mRNA-1273 group ( p < 0.001). The BNT162b2 group reported less prevalence of all adverse reactions. Need for medical leave was significantly more frequent among the mRNA-1273 group (12% versus 4.6% p < 0.001). Interestingly, respondents with a history of allergies or chronic illnesses did not report more adverse reactions. The frequency of adverse reactions with dose 2 was 96% (95% CI 88–100%) for those with a history of COVID-19 related hospitalization, and 86% (95% CI 83–89%) for those with mild or moderate symptomatic COVID-19, significantly higher than for participants with no history of COVID-19 infections (67%, 95% CI 65–69%). Our results could help inform vaccine recipients of the probability of their having adverse reactions to COVID-19 vaccines.
【저자키워드】 SARS-CoV-2, Healthcare workers, mRNA vaccines, Adverse reactions, COVID-19-vaccination, 【초록키워드】 COVID-19, Vaccine, BNT162b2 vaccine, Hospitalization, mRNA-1273, cross-sectional, hospital, healthcare worker, BNT162b2, Prevalence, Probability, COVID-19 vaccines, COVID-19 infection, symptomatic, Spain, Mild, allergy, moderate, questionnaire, Frequency, dose, Adverse reaction, Barcelona, mRNA-1273 COVID-19 vaccine, Chronic illness, mRNA-1273 vaccine, 95% CI, COVID-19 infections, help, participant, recipient, significantly more, reported, conducted, less, significantly higher, 【제목키워드】 COVID-19, mRNA, systemic, Adverse, reaction, Type,