Coronavirus disease 2019 (COVID-19) vaccination began for healthcare workers in South Korea at the end of February 2021. This study investigated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody responses after various COVID-19 vaccinations in healthcare workers. Blood specimens of 497 vaccinated healthcare workers were collected. Inoculated vaccines were ChAdOx1 (AstraZeneca/Oxford), BNT162b2 (Pfizer/BioNTech), JNJ-78436735 (Janssen), and mRNA-1273 (Moderna). Each specimen was tested for antibodies against SARS-CoV-2 using Elecsys Anti-SARS-CoV-2 S assay (Roche Diagnostics), SARS-CoV-2 IgG II Quant assay (Abbott), and R-FIND SARS-CoV-2 Neutralizing Antibody kit (SG medical Inc.). A questionnaire was used to investigate adverse events related to vaccination. We found that 99.5% of the subjects showed a 96–100% positive rate in all three antibody assays, regardless of the vaccine type. The antibody-positive rate of completed vaccination groups reached 96–100%, and antibody quantities significantly increased 2 weeks after vaccination. The antibody values measured approximately 3 months after BNT162b2 inoculation significantly correlated with adverse events.
【저자키워드】 neutralizing antibody, COVID-19 vaccine, Pfizer-BioNTech, AstraZeneca-Oxford, Elecsys Anti-SARS-CoV-2 S assay, Abbott SARS-CoV-2 IgG II Quant assay, 【초록키워드】 COVID-19, SARS-CoV-2, Coronavirus disease 2019, Vaccine, coronavirus, vaccination, antibody, mRNA-1273, Antibody Response, healthcare worker, BNT162b2, adverse events, COVID-19 vaccination, healthcare, adverse event, group, South Korea, positive rate, questionnaire, ChAdOx1, SARS-CoV-2 IgG, Moderna, Antibody assays, Pfizer/BioNTech, janssen, Abbott, acute respiratory syndrome, blood specimen, subject, specimen, Roche Diagnostics, JNJ-78436735, significantly increased, was used, collected, significantly, investigated, correlated, reached, the vaccine, Elecsy, Inc., was tested, 【제목키워드】 COVID-19, SARS-CoV-2, response, worker,