Systemic vaccination with the BNT162b2 mRNA vaccine stimulates the humoral response. Our study aimed to compare the intensity of the humoral immune response, measured by SARS-CoV-2 IgG, SARS-CoV-2 IgM, and S-RBD-neutralizing IgG antibody levels after COVID-19 vaccination versus after SARS-CoV-2 infection. We analyzed 1060 people in the following groups: convalescents; healthy unvaccinated individuals; individuals vaccinated with Comirnaty, AstraZeneca, Moderna, or Johnson & Johnson; and vaccinated SARS-CoV-2 convalescents. The concentrations of SARS-CoV-2 IgG, SARS-CoV-2 IgM, and S-RBD-neutralizing antibodies were estimated in an oncology hospital laboratory by chemiluminescent immunoassay (CLIA; MAGLUMI). Results: (1) We observed a rise in antibody response in both the SARS-CoV-2 convalescent and COVID-19-vaccinated groups. (2) The levels of all antibody concentrations in vaccinated COVID-19 convalescents were significantly higher. (3) We differentiated asymptomatic SARS-CoV-2 convalescents from the control group. Our analysis suggests that monitoring SARS-CoV-2 IgG antibody concentrations is essential as an indicator of asymptomatic COVID-19 and as a measure of the effectiveness of the humoral response in convalescents and vaccinated people. Considering the time-limited effects of post-SARS-CoV-2 infection recovery or vaccination and the physiological half-life, among other factors, we suggest monitoring IgG antibody levels as a criterion for future vaccination.
【저자키워드】 COVID-19, SARS-CoV-2, vaccination, BNT162b2, reimmunization, 【초록키워드】 antibody, SARS-COV-2 infection, hospital, Antibody Response, Infection, Laboratory, IgG antibody, Asymptomatic, COVID-19 vaccination, SARS-CoV-2 IgG antibody, Effectiveness, Factors, humoral immune response, chemiluminescent immunoassay, convalescent, SARS-CoV-2 IgG, AstraZeneca, SARS-CoV-2 IgM, BNT162b2 mRNA vaccine, Moderna, Concentration, Analysis, physiological, humoral, systemic, antibody concentration, Asymptomatic COVID-19, intensity, oncology, control group, individual, criterion, Effect, analyzed, healthy, significantly higher, groups, stimulate, the SARS-CoV-2, 【제목키워드】 Poland, Population, response, systemic,