Abstract Coronavirus disease (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been declared a pandemic. We herein report four COVID-19 cases with long-term positive viral ribonucleic acid (RNA) for about 61 days. Despite treatment with recombinant human interferon, convalescent plasma from COVID-19 patients, arbidol, etc., nucleic acid results were still positive for SARS-CoV-2. After treatment with ritonavir-boosted danoprevir (DNVr, 100/100 mg, once daily), all four patients showed two to three consecutive negative SARS-CoV-2 RNA and were thus discharged from hospital. Therefore, DNVr may be a potentially effective antiviral for COVID-19 patients with long-term positive SARS-CoV-2 RNA.
【저자키워드】 COVID-19, antivirals, Long-term positive SARS-CoV-2, 【초록키워드】 Treatment, convalescent plasma, SARS-CoV-2, coronavirus, pandemic, Antiviral, hospital, interferon, RNA, nucleic acid, Patient, SARS-CoV-2 RNA, disease, COVID-19 patients, COVID-19 patient, acute respiratory syndrome, COVID-19 case, viral ribonucleic acid, positive, effective, caused, discharged, 【제목키워드】 coronavirus, Antiviral, Case report, Patient, acute respiratory syndrome, therapeutic effect, positive,