Background: A nocebo effect occurs when inactive factors lead to worsening of symptoms or reduce treatment outcomes. Believing that one is or has been infected with COVID-19 may act as a nocebo. However, not much is known about potential nocebo effects associated with the reporting of COVID-19 symptoms. Aim: An online survey investigated whether certainty of being infected with COVID-19, age, sex, cognitive, emotional and personality factors were associated with perceived severity of COVID-19 symptoms. Methods: Participants ( N =375) filled out an online survey containing 57 questions asking about symptoms resembling COVID-19, certainty of being infected with COVID-19, anxiety, stress and personality dimensions. Results: Certainty of being infected with COVID-19 and anxiety predicted 27% of the variance in reporting of COVID-like symptoms. The mediation analysis showed that both higher certainty of being infected and anxiety independently predicted increased reports of COVID-like symptom. Females had higher anxiety and stress levels, and reported more COVID-like symptoms than males did. Older age was not associated with reporting COVID-like symptoms. Conclusions: Believing to be infected with COVID-19, along with anxiety, can enhance the severity of COVID-like symptoms. Thus, the nocebo effect was due to both cognitive and emotional factors and was higher in females.
【저자키워드】 COVID-19, coronavirus, psychological factors, negative emotions, nocebo effect, 【초록키워드】 Treatment, Anxiety, Stress, severity, Sex, Symptom, Symptoms, outcomes, severity of COVID-19, male, age, Mediation analysis, COVID-19 symptoms, emotional, cognitive, Factor, worsening, certainty, participant, stress levels, dimensions, Effect, females, ENhance, predicted, reported, investigated, question, occur, reduce, inactive, infected with COVID-19, 【제목키워드】 Symptom, COVID-19 symptom,