Background The clinical and virological course of patients with coronavirus disease 2019 (COVID-19) are lacking. We aimed to describe the clinical and virological characteristics of COVID-19 patients from 10 designated hospitals in 10 cities of Jiangsu province, China. The factors associated with the clearance of SARS-CoV-2 were investigated. Methods A total of 328 hospitalized patients with COVID-19 were retrospectively recruited. The epidemiological, clinical, laboratory, radiology and treatment data were collected. The associated factors of SARS-CoV-2 clearance were analyzed. Results The median duration of hospitalization was 16.0 days (interquartile range [IQR] 13.0–21.0 days). On multivariate Cox regression analysis, age > 60 years (hazard ratio [HR] 0.643, 95% confidence interval [CI] 0.454–0.911, P = 0.013) was associated with the delayed SARS-CoV-2 clearance, while the atomized inhalation of interferon α-2b could improve the clearance of SARS-CoV-2 (HR, 1.357, 95% CI 1.050–1.755, P = 0.020). Twenty-six (7.9%) patients developed respiratory failure and 4 (1.2%) patients developed ARDS. Twenty (6.1%) patients were admitted to the ICU, while no patient was deceased. Conclusions Our study found that age > 60 years was associated with the delayed SARS-CoV-2 clearance, while treated with atomized inhalation of interferon α-2b could promote the clearance of SARS-CoV-2. Supplementary Information The online version contains supplementary material available at 10.1186/s12985-021-01615-y.
【저자키워드】 SARS-CoV-2, Coronavirus disease 2019, Viral, clearance, 【초록키워드】 COVID-19, Treatment, coronavirus disease, ARDS, Respiratory failure, hospital, interferon, ICU, Laboratory, China, Characteristics, Patient, epidemiological, Analysis, Deceased, COVID-19 patient, interquartile range, Factor, Virological, supplementary material, 95% CI, 95% confidence interval, hazard ratio, multivariate Cox regression, SARS-CoV-2 clearance, duration of hospitalization, Jiangsu, IMPROVE, Course, Result, analyzed, collected, recruited, investigated, median, treated, hospitalized patient, promote, clearance of SARS-CoV-2, with COVID-19, 【제목키워드】 coronavirus disease, cohort study, clinical, Patient, retrospective, Virological, Jiangsu, Course,