Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel coronavirus in humans, has expanded globally over the past year. COVID-19 remains an important subject of intensive research owing to its huge impact on economic and public health globally. Based on historical archives, the first coronavirus-related disease recorded was possibly animal-related, a case of feline infectious peritonitis described as early as 1912. Despite over a century of documented coronaviruses in animals, the global animal industry still suffers from outbreaks. Knowledge and experience handling animal coronaviruses provide a valuable tool to complement our understanding of the ongoing COVID-19 pandemic. In this review, we present an overview of coronaviruses, clinical signs, COVID-19 in animals, genome organization and recombination, immunopathogenesis, transmission, viral shedding, diagnosis, treatment, and prevention. By drawing parallels between COVID-19 in animals and humans, we provide perspectives on the pathophysiological mechanisms by which coronaviruses cause diseases in both animals and humans, providing a critical basis for the development of effective vaccines and therapeutics against these deadly viruses.
【저자키워드】 COVID-19, Immunopathogenesis, DIVA, animal coronavirus, 【초록키워드】 Treatment, viruses, public health, SARS-CoV-2, Coronavirus disease 2019, Coronaviruses, coronavirus, COVID-19 pandemic, viral shedding, Diagnosis, Transmission, complement, Novel coronavirus, Outbreaks, humans, Research, Recombination, Clinical signs, disease, Intensive, Critical, acute respiratory syndrome, subject, Perspective, pathophysiological mechanism, handling, genome organization, described, caused, animal coronavirus, effective vaccine, recorded, 【제목키워드】 Human, animal, with COVID-19,