Respiratory viruses infect the human upper respiratory tract, mostly causing mild diseases. However, in vulnerable populations, such as newborns, infants, the elderly and immune-compromised individuals, these opportunistic pathogens can also affect the lower respiratory tract, causing a more severe disease (e.g., pneumonia). Respiratory viruses can also exacerbate asthma and lead to various types of respiratory distress syndromes. Furthermore, as they can adapt fast and cross the species barrier, some of these pathogens, like influenza A and SARS-CoV, have occasionally caused epidemics or pandemics, and were associated with more serious clinical diseases and even mortality. For a few decades now, data reported in the scientific literature has also demonstrated that several respiratory viruses have neuroinvasive capacities, since they can spread from the respiratory tract to the central nervous system (CNS). Viruses infecting human CNS cells could then cause different types of encephalopathy, including encephalitis, and long-term neurological diseases. Like other well-recognized neuroinvasive human viruses, respiratory viruses may damage the CNS as a result of misdirected host immune responses that could be associated with autoimmunity in susceptible individuals (virus-induced neuro-immunopathology) and/or viral replication, which directly causes damage to CNS cells (virus-induced neuropathology). The etiological agent of several neurological disorders remains unidentified. Opportunistic human respiratory pathogens could be associated with the triggering or the exacerbation of these disorders whose etiology remains poorly understood. Herein, we present a global portrait of some of the most prevalent or emerging human respiratory viruses that have been associated with possible pathogenic processes in CNS infection, with a special emphasis on human coronaviruses.
【저자키워드】 Encephalitis, Human coronavirus, neuroinvasion, Encephalopathy, respiratory viral infection, human respiratory virus, CNS infection, acute and chronic neurological diseases, 【초록키워드】 viruses, Autoimmunity, Asthma, Diseases, Mortality, Pneumonia, SARS-CoV, Infection, Epidemics, influenza A, Spread, Infants, Host immune response, pathogen, viral replication, Pandemics, Mild, Pathogens, Central nervous system, cross, respiratory tract, respiratory, etiology, CNS, upper respiratory tract, human coronaviruses, Neurological disorder, distress, severe disease, Lower respiratory tract, Neuroinvasive, respiratory pathogen, etiological agent, disorder, Neurological diseases, clinical disease, triggering, infecting, infect, Affect, populations, Cell, prevalent, caused, virus, respiratory virus, reported, demonstrated, Like, cause, individuals, pathogenic processe, human respiratory virus, exacerbate, susceptible individual, 【제목키워드】 Human, respiratory, Other, nervous,