Severe acute respiratory coronavirus-2 syndrome (SARS-CoV-2) is a well-known pandemic infectious disease caused by an RNA virus belonging to the coronaviridae family. The most important involvement during the acute phase of infection concerns the respiratory tract and may be fatal. However, COVID-19 may become a systemic disease with a wide spectrum of manifestations. Herein, we report the natural history of sacroiliac inflammatory involvement in two females who developed COVID-19 infection with mild flu-like symptoms. After the infection they reported inflammatory back pain, with magnetic resonance imaging (MRI) studies showing typical aspects of sacroiliitis. Symptoms improved with NSAIDs therapy over the following months while MRI remained positive. A literature review was performed on this emerging topic. To our knowledge, this is the first MRI longitudinal study of post-COVID-19 sacroiliitis with almost one year of follow-up. Predisposing factors for the development of articular involvement are unclear but a long-lasting persistence of the virus, demonstrated by nasopharyngeal swab, may enhance the probability of altering the immune system in a favourable background.
【저자키워드】 COVID-19, Arthritis, sacroiliitis, post-COVID-19 manifestations, 【초록키워드】 SARS-CoV-2, pandemic, therapy, magnetic resonance imaging, knowledge, Infection, Infectious disease, immune system, virus, MRI, Probability, Nasopharyngeal swab, COVID-19 infection, persistence, female, Manifestations, Follow-up, respiratory tract, RNA virus, disease, Coronavirus-2, NSAID, Inflammatory, predisposing factor, literature review, Topic, back pain, acute phase, syndrome, positive, ENhance, caused, reported, remained, was performed, demonstrated, long-lasting, mild flu-like symptoms, 【제목키워드】 review, imaging, literature, longitudinal, history, natural, resonance,