Severe acute respiratory syndrome (SARS)-like WIV1-coronavirus (CoV) was first isolated from Rhinolophus sinicus bats and can use the human angiotensin converting enzyme 2 (ACE2) receptor. In the current study, we investigate the ability of WIV1-CoV to infect Rousettus aegyptiacus bats. No clinical signs were observed throughout the experiment. Furthermore, only four oropharyngeal swabs and two respiratory tissues, isolated on day 3 post inoculation, were found positive for viral RNA. Two out of twelve bats showed a modest increase in coronavirus specific antibodies post challenge. In conclusion, WIV1-CoV was unable to cause a robust infection in Rousettus aegyptiacus bats.
All Keywords
【저자키워드】 coronavirus, Emerging infectious diseases, animal model, WIV1-CoV, 【초록키워드】 ACE2, Infection, oropharyngeal swab, CoV, bat, Viral RNA, receptor, experiment, bats, acute respiratory syndrome, enzyme, respiratory tissues, positive, Clinical sign, infect, post inoculation, robust, specific antibody, increase in, Rousettus, 【제목키워드】 bat, fruit, Rousettus,
【저자키워드】 coronavirus, Emerging infectious diseases, animal model, WIV1-CoV, 【초록키워드】 ACE2, Infection, oropharyngeal swab, CoV, bat, Viral RNA, receptor, experiment, bats, acute respiratory syndrome, enzyme, respiratory tissues, positive, Clinical sign, infect, post inoculation, robust, specific antibody, increase in, Rousettus, 【제목키워드】 bat, fruit, Rousettus,