In 2019 an outbreak occurred which resulted in a global pandemic. The causative agent has been identified in a virus belonging to the Coronaviridae family, similar to the agent of SARS, referred to as SARS-CoV-2. This epidemic spread rapidly globally with high morbidity and mortality. Although vaccine development is at a very advanced stage, there are currently no truly effective antiviral drugs to treat SARS-CoV-2 infection. In this study we present systematic and integrative antiviral drug repurposing effort aimed at identifying, among the drugs already authorized for clinical use, some active inhibitors of the SARS-CoV-2 main protease. The most important result of this analysis is the demonstration that ethacrynic acid, a powerful diuretic, is revealed to be an effective inhibitor of SARS-CoV-2 main protease. Even with all the necessary cautions, given the particular nature of this drug, these data can be the starting point for the development of an effective therapeutic strategy against SARS-CoV-2.
【저자키워드】 COVID-19, Drug repurposing, SARS-CoV-2, coronavirus, main protease, 3CL Protease, protease inhibitors, 3C-like protease, MPro, 【초록키워드】 Vaccine development, SARS-COV-2 infection, drug, protease, virus, SARS-CoV-2 main protease, antiviral drug, global pandemic, Spread, Epidemic, outbreak, morbidity and mortality, inhibitor, therapeutic strategy, Analysis, starting point, Clinical use, These data, effort, treat, effective inhibitor, effective, occurred, the Coronaviridae, the SARS-CoV-2, 【제목키워드】 drug, acid, Potential,