The emergence of novel viral infections of zoonotic origin and mutations of existing human pathogenic viruses represent a serious concern for public health. It warrants the establishment of better interventions and protective therapies to combat the virus and prevent its spread. Surface glycoproteins catalyzing the fusion of viral particles and host cells have proven to be an excellent target for antivirals as well as vaccines. This review focuses on recent advances for computational structure-based design of antivirals and vaccines targeting viral fusion machinery to control seasonal and emerging respiratory viruses.
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【저자키워드】 Vaccine, respiratory viruses, Glycoproteins, computational protein design, structural vaccinology, rational design, 【초록키워드】 public health, viral infection, therapy, Mutation, Antiviral, Vaccines, Intervention, virus, Spread, glycoprotein, structure-based design, surface, Protective, host cell, emerging respiratory viruses, zoonotic origin, viral particle, pathogenic virus, Prevent, 【제목키워드】 surface, targeting,
【저자키워드】 Vaccine, respiratory viruses, Glycoproteins, computational protein design, structural vaccinology, rational design, 【초록키워드】 public health, viral infection, therapy, Mutation, Antiviral, Vaccines, Intervention, virus, Spread, glycoprotein, structure-based design, surface, Protective, host cell, emerging respiratory viruses, zoonotic origin, viral particle, pathogenic virus, Prevent, 【제목키워드】 surface, targeting,