Respiratory viruses infections caused by influenza viruses, human parainfluenza virus (hPIV), respiratory syncytial virus (RSV) and coronaviruses are an eminent threat for public health. Currently, there are no licensed vaccines available for hPIV, RSV and coronaviruses, and the available seasonal influenza vaccines have considerable limitations. With regard to pandemic preparedness, it is important that procedures are in place to respond rapidly and produce tailor made vaccines against these respiratory viruses on short notice. Moreover, especially for influenza there is great need for the development of a universal vaccine that induces broad protective immunity against influenza viruses of various subtypes. Modified Vaccinia Virus Ankara (MVA) is a replication-deficient viral vector that holds great promise as a vaccine platform. MVA can encode one or more foreign antigens and thus functions as a multivalent vaccine. The vector can be used at biosafety level 1, has intrinsic adjuvant capacities and induces humoral and cellular immune responses. However, there are some practical and regulatory issues that need to be addressed in order to develop MVA-based vaccines on short notice at the verge of a pandemic. In this review, we discuss promising novel influenza virus vaccine targets and the use of MVA for vaccine development against various respiratory viruses.
【저자키워드】 Vaccine development, coronavirus, Influenza virus, respiratory syncytial virus, modified vaccinia virus Ankara, parainfluenza virus, 【초록키워드】 public health, Coronaviruses, Vaccine, pandemic, Influenza, Infection, biosafety, respiratory viruses, Regulatory, protective immunity, RSV, influenza viruses, target, vaccine platform, respiratory, function, multivalent vaccine, humoral, Seasonal influenza, human parainfluenza virus, Subtypes, cellular immune responses, vaccinia, limitations, intrinsic, develop, caused, virus, respiratory virus, can be used, coronavirus, influenza virus, induce, addressed, respond, foreign antigen, replication-deficient viral vector, 【제목키워드】 Production, respiratory, Other, vaccinia,