The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on the world is still expanding. Thus, there is an urgent need to better understand this novel virus and find a way to control its spread. Like other coronaviruses, the nucleocapsid (N) protein is one of the most crucial structural components of SARS-CoV-2. This protein shares 90% homology with the severe acute respiratory syndrome coronavirus N protein, implying functional significance. Based on the evolutionary conservation of the N protein in coronavirus, we reviewed the currently available knowledge regarding the SARS-CoV-2 N protein in terms of structure, biological functions, and clinical application as a drug target or vaccine candidate.
【저자키워드】 Structure, SARS-CoV-2, Vaccine, nucleocapsid protein, biological function, 【초록키워드】 Biological functions, coronavirus, knowledge, virus, Spread, Protein, nucleocapsid, N protein, drug target, vaccine candidate, acute respiratory syndrome, other coronaviruses, homology, component, functional, Like, the N protein, the SARS-CoV-2, 【제목키워드】 drug, Mitigation, target, Biological, role, Potential,