Monocytes are key modulators in acute viral infections, determining both inflammation and development of specific B- and T-cell responses. Recently, these cells were shown to be associated to different SARS-CoV-2 infection outcome. However, their role in acute HIV-1 infection remains unclear. We had the opportunity to evaluate the mononuclear cell compartment in an early hyper-acute HIV-1 patient in comparison with an untreated chronic HIV-1 and a cohort of SARS-CoV-2 infected patients, by high dimensional flow cytometry using an unsupervised approach. A distinct polarization of the monocyte phenotype was observed in the two viral infections, with maintenance of pro-inflammatory M1-like profile in HIV-1, in contrast to the M2-like immunosuppressive shift in SARS-CoV-2. Noticeably, both acute infections had reduced CD14 low/− CD16 + non-classical monocytes, with depletion of the population expressing Slan (6-sulfo LacNac), which is thought to contribute to immune surveillance through pro-inflammatory properties. This depletion indicates a potential role of these cells in acute viral infection, which has not previously been explored. The inflammatory state accompanied by the depletion of Slan+ monocytes may provide new insights on the critical events that determine the rate of viral set-point in acute HIV-1 infection and subsequent impact on transmission and reservoir establishment.
【저자키워드】 COVID-19, Monocytes, dendritic cells, Slan, acute HIV-1 infection, M-DC8, 【초록키워드】 SARS-CoV-2, Inflammation, SARS-COV-2 infection, Transmission, outcome, viral infections, flow cytometry, immune, monocyte, Non-classical monocytes, Cohort, Surveillance, acute infection, HIV-1, Patient, phenotype, Critical, T-cell responses, CD16, immunosuppressive, inflammatory state, mononuclear cell, SARS-CoV-2 infected patients, acute viral infection, CD14, HIV-1 infection, pro-inflammatory, acute viral infections, approach, event, thought, shown, evaluate, subsequent, reduced, indicate, determine, contribute, expressing, these cell, accompanied, 【제목키워드】 SARS-CoV-2, HIV-1, report,