Severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 are enveloped, positive-sense, single-stranded RNA viruses and causes of epidemic diseases that have resulted in public health emergencies worldwide. Angiotensin-converting enzyme 2 (ACE2) is the receptor that allows the entry of these two viruses into host cells, a key step in the life cycle of the pathogens. The characterization of the interactions of ACE2 with the viral spike glycoproteins and structural studies of the ACE2-binding-induced conformational changes in the viral spike glycoproteins have furthered our understanding of the entry processes of these two viruses, and these studies provide useful information that will facilitate the development of antiviral agents and vaccines to control the diseases.
【저자키워드】 COVID-19, spike glycoprotein, membrane fusion, Entry, Receptor binding, conformational change, SARS coronaviruses, 【초록키워드】 viruses, SARS-CoV-2, ACE2, Vaccine, coronavirus, Diseases, SARS-CoV, virus, Pathogens, glycoprotein, receptor, public health emergency, antiviral agent, information, Interaction, host cells, epidemic disease, acute respiratory syndrome, enzyme, viral spike, single-stranded RNA virus, positive-sense, facilitate, cause, 【제목키워드】 spike,