Around two percent of asymptomatic women in labor test positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Spain. Families and care providers face childbirth with uncertainty. We determined if SARS-CoV-2 infection at delivery among asymptomatic mothers had different obstetric outcomes compared to negative patients. This was a multicenter prospective study based on universal antenatal screening for SARS-CoV-2 infection. A total of 42 hospitals tested women admitted for delivery using polymerase chain reaction, from March to May 2020. We included positive mothers and a sample of negative mothers asymptomatic throughout the antenatal period, with 6-week postpartum follow-up. Association between SARS-CoV-2 and obstetric outcomes was evaluated by multivariate logistic regression analyses. In total, 174 asymptomatic SARS-CoV-2 positive pregnancies were compared with 430 asymptomatic negative pregnancies. No differences were observed between both groups in key maternal and neonatal outcomes at delivery and follow-up, with the exception of prelabor rupture of membranes at term (adjusted odds ratio 1.88, 95% confidence interval 1.13–3.11; p = 0.015). Asymptomatic SARS-CoV-2 positive mothers have higher odds of prelabor rupture of membranes at term, without an increase in perinatal complications, compared to negative mothers. Pregnant women testing positive for SARS-CoV-2 at admission for delivery should be reassured by their healthcare workers in the absence of symptoms.
【저자키워드】 SARS-CoV-2, coronavirus, Pregnancy, delivery, perinatal outcomes, maternal complications, asymptomatic infection, 【초록키워드】 SARS-COV-2 infection, hospital, Prospective Study, outcome, Symptoms, healthcare worker, family, Asymptomatic, Spain, membrane, complications, Follow-up, women, multicenter, Admission, Care, patients, mother, Neonatal, Obstetric, Antenatal, acute respiratory syndrome, adjusted odds ratio, 95% confidence interval, multivariate logistic regression, positive, pregnancies, rupture, polymerase chain, tested, evaluated, absence, increase in, analyses, both group, higher odd,