With the rapid global spread of the Coronavirus Disease 2019 (COVID-19) pandemic, a safe and effective vaccine against human coronaviruses (HCoVs) is believed to be a top priority in the field of public health. Due to the frequent outbreaks of different HCoVs, the development of a pan-HCoVs vaccine is of great value to biomedical science. The antigen design is a key prerequisite for vaccine efficacy, and we therefore developed a novel antigen with broad coverage based on the genetic algorithm of mosaic strategy. The designed antigen has a potentially broad coverage of conserved cytotoxic T lymphocyte (CTL) epitopes to the greatest extent, including the existing epitopes from all reported HCoV sequences (HCoV-NL63, HCoV-229E, HCoV-OC43, HCoV-HKU1, SARS-CoV, MERS-CoV, and SARS-CoV-2). This novel antigen is expected to induce strong CTL responses with broad coverage by targeting conserved epitopes against multiple coronaviruses.
【저자키워드】 coronavirus, antigen design, pan-vaccine, conserved epitopes, 【초록키워드】 COVID-19, public health, SARS-CoV-2, Efficacy, Vaccine, pandemic, SARS-CoV, Genetic, HCoV-OC43, HCoV-HKU1, MERS-CoV, Antigen, Spread, Coverage, outbreak, response, Algorithm, HCoV-229E, epitope, CTL, HCoV-NL63, Safe, sequence, multiple coronaviruses, cytotoxic T lymphocyte, effective, human coronavirus, conserved, reported, induce, expected, 【제목키워드】 CTL,