Human coronaviruses cause both upper and lower respiratory tract infections in humans. In 2012, a sixth human coronavirus (hCoV) was isolated from a patient presenting with severe respiratory illness. The 60-year-old man died as a result of renal and respiratory failure after admission to a hospital in Jeddah, Saudi Arabia. The aetiological agent was eventually identified as a coronavirus and designated Middle East respiratory syndrome coronavirus (MERS-CoV). MERS-CoV has now been reported in more than 27 countries across the Middle East, Europe, North Africa and Asia. As of July 2017, 2040 MERS-CoV laboratory confirmed cases, resulting in 712 deaths, were reported globally, with a majority of these cases from the Arabian Peninsula. This review summarises the current understanding of MERS-CoV, with special reference to the (i) genome structure; (ii) clinical features; (iii) diagnosis of infection; and (iv) treatment and vaccine development.
【저자키워드】 MERS-CoV, Clinical features, respiratory viruses, lower respiratory tract infections, upper respiratory tract infections, human coronavirus, 【초록키워드】 Treatment, Vaccine development, coronavirus, Europe, Respiratory failure, hospital, Human, Genome, Infection, Diagnosis, Saudi Arabia, Laboratory, Asia, Jeddah, humans, HCoV, Patient, severe respiratory illness, Admission, deaths, Lower respiratory tract, Middle East, Arabian Peninsula, confirmed cases, North, respiratory syndrome coronavirus, renal, country, resulting, died, reported, majority, presenting, 【제목키워드】 threat, understanding,