The role of the adaptive microenvironment components in severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) infection is widely researched, but remains unclear. Studying the common dynamics of adaptive immune response changes can help understand the pathogenesis of coronavirus disease 2019 (COVID-19), especially in critical patients. The aim of the present study was to determine the cytokines concentration and leukocyte subpopulations profiles in the severe COVID-19 ( n = 23) and critical ( n = 18) COVID-19 group distinguished by the computed tomography (CT) severity score. We observed lower percentage of lymphocyte subpopulation, higher neutrophils to lymphocytes ratio (NLR) and higher IL-6 concentration in critical COVID-19 group than in severe group. CT severity score was negative correlated with proportion of lymphocytes, lymphocytes T, CD4+ cells, Treg cells and NK cells and positive correlated with neutrophils, NLR, and IL-6. In critical group more correlations between cytokines and lymphocytes were observed, mainly between TNF-α, IL-1β and lymphocyte subpopulations. The collective assessment of the cytokine profile, leukocyte subpopulations and the CT severity score can help to characterize and differentiate patient in advanced COVID-19 than the study of single parameters. We have shown that the interconnection of elements of the adaptive microenvironment can play an important role in critical COVID-19 cases.
【저자키워드】 SARS-CoV-2, Cytokines, IL-6, Computed tomography, lymphocyte, TNF-α, IL-1β, CT severity score, leukocyte, T regulatory cell, 【초록키워드】 COVID-19, coronavirus disease, Neutrophils, coronavirus, Pathogenesis, Lymphocytes, adaptive, severe COVID-19, severity, neutrophil, Infection, NK cell, cytokine, Patient, Adaptive immune response, correlation, change, Critical, parameters, patients, cytokine profile, TNF-α, NLR, IL-1β, Concentration, COVID-19 cases, acute respiratory syndrome, profile, severe group, help, COVID-19 group, component, positive, subpopulations, element, subpopulation, microenvironment, CD4+ cells, shown, proportion, determine, correlated, lymphocyte subpopulation, Treg cell, 【제목키워드】 score, profile,