The H1N1 pandemic of 2009-2010, MERS epidemic of 2012, Ebola epidemics of 2013-2016 and 2018-2020, Zika epidemic of 2015-2016, and COVID-19 pandemic of 2019-2021, are recent examples in the long history of epidemics that demonstrate the enormous global impact of viral infection. The rapid development of safe and effective vaccines and therapeutics has proven vital to reducing morbidity and mortality from newly emerging viruses. Structural biology methods can be used to determine how antibodies elicited during infection or vaccination target viral proteins and identify viral epitopes that correlate with potent neutralization. Here we review how structural and molecular biology approaches have contributed to our understanding of antibody recognition of pathogenic viruses, specifically HIV-1, SARS-CoV-2, and Zika. Determining structural correlates of neutralization of viruses has guided the design of vaccines, monoclonal antibodies, and small molecule inhibitors in response to the global threat of viral epidemics.
【저자키워드】 SARS-CoV-2, structural biology, antibody, Cryo-electron microscopy, X-ray crystallography, virus, HIV-1, Zika, 【초록키워드】 viruses, viral infection, vaccination, Molecular biology, Vaccines, neutralization, COVID-19 pandemic, Infection, Epidemics, MERS, monoclonal antibodies, Epidemic, Ebola, morbidity and mortality, epitope, Safe, Viral protein, pathogenic viruses, viral epidemics, H1N1 pandemic, identify, approach, virus, example, can be used, determine, reducing, contributed, effective vaccine, elicited, Determining, small molecule inhibitor,