P-selectin glycoprotein ligand-1 (PSGL-1) is a cell surface glycoprotein that binds to P-, E-, and L-selectins to mediate the tethering and rolling of immune cells on the surface of the endothelium for cell migration into inflamed tissues. PSGL-1 has been identified as an interferon-γ (INF-γ)-regulated factor that restricts HIV-1 infectivity, and has recently been found to possess broad-spectrum antiviral activities. Here we report that the expression of PSGL-1 in virus-producing cells impairs the incorporation of SARS-CoV and SARS-CoV-2 spike (S) glycoproteins into pseudovirions and blocks pseudovirus attachment and infection of target cells. These findings suggest that PSGL-1 may potentially inhibit coronavirus replication in PSGL-1 + cells
【저자키워드】 coronavirus, cellular antiviral factor, pseudovirion, 【초록키워드】 SARS-CoV, Infection, P-selectin, Endothelium, L-selectin, Surface glycoprotein, pseudovirus, HIV-1, glycoprotein, expression, SARS-CoV-2 spike, Immune cell, Coronavirus replication, Cell migration, target cells, antiviral activities, interferon-γ, inflamed tissues, block, PSGL-1, Cell, bind, inhibit, restrict, impair, virus-producing cell, 【제목키워드】 SARS-CoV-2, spike, SARS-CoV, Infectivity, glycoprotein, attachment, incorporation, PSGL-1,