The COVID-19 pandemic has hugely impacted global public health and economy. The COVID-19 has also shown potential impacts on maternal perinatal and neonatal outcomes. This systematic review aimed to summarize the evidence from existing systematic reviews about the effects of SARS-CoV-2 infections on maternal perinatal and neonatal outcomes. We searched PubMed, MEDLINE, Embase, and Web of Science in accordance with PRISMA guidelines, from 1 December 2019 to 7 July 2021, for published review studies that included case reports, primary studies, clinical practice guidelines, overviews, case-control studies, and observational studies. Systematic reviews that reported the plausibility of mother-to-child transmission of COVID-19 (also known as vertical transmission), maternal perinatal and neonatal outcomes, and review studies that addressed the effect of SARS-CoV-2 infection during pregnancy were also included. We identified 947 citations, of which 69 studies were included for further analysis. Most (>70%) of the mother-to-child infection was likely due to environmental exposure, although a significant proportion (about 20%) was attributable to potential vertical transmission of SARS-CoV-2. Further results of the review indicated that the mode of delivery of pregnant women infected with SARS-CoV-2 could not increase or decrease the risk of infection for the newborns (outcomes), thereby emphasizing the significance of breastfeeding. The issue of maternal perinatal and neonatal outcomes with SARS-CoV-2 infection continues to worsen during the ongoing COVID-19 pandemic, increasing maternal and neonatal mortality, stillbirth, ruptured ectopic pregnancies, and maternal depression. Based on this study, we observed increasing rates of cesarean delivery from mothers with SARS-CoV-2 infection. We also found that SARS-CoV-2 could be potentially transmitted vertically during the gestation period. However, more data are needed to further investigate and follow-up, especially with reports of newborns infected with SARS-CoV-2, in order to examine a possible long-term adverse effect.
【저자키워드】 COVID-19, pandemic, systematic review, Pregnancy, vertical transmission, 【초록키워드】 SARS-CoV-2, Breastfeeding, Depression, SARS-COV-2 infection, COVID-19 pandemic, Infection, Transmission, outcome, observational studies, pregnant women, outcomes, Newborn, Stillbirth, Impact, environmental exposure, Follow-up, Clinical practice, mother, case-control studies, Evidence, Analysis, risk of infection, Neonatal, adverse effect, Web of Science, Neonatal Mortality, global public health, pregnancies, MOST, transmission of SARS-CoV-2, Effect, decrease, shown, proportion, reported, indicated, transmitted, searched, addressed, impacted, ectopic, gestation period, infected with SARS-CoV-2, 【제목키워드】 review, vertical,