Background: The prevalence and prognostic implications of metabolic syndrome (MetS) in patients infected by the SARS-CoV-2 remain unclear. We performed a systematic review and meta-analysis of prevalence and mortality risk in COVID-19 patients with MetS. Methods: Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed in abstracting data and assessing validity. We searched MEDLINE and Scopus to locate every article published up to 1 September 2021, reporting data on MetS among COVID-19 patients. The pooled prevalence of MetS was calculated using a random effects model and presented using the related 95% confidence interval (CI), while the mortality risk was estimated using the Mantel-Haenszel random effects models with odds ratio (OR) and related 95% CI. Statistical heterogeneity was measured using the Higgins I 2 statistic. Results: Six studies, enrolling 209.569 COVID-19 patients [mean age 57.2 years, 114.188 males (54.4%)] met the inclusion criteria and were included in the final analysis. The pooled prevalence of dyslipidaemia was 20.5% of cases (95% CI: 6.7–47.8%, p = 0.03), with high heterogeneity (I 2 = 98.9%). Pre-existing MetS was significantly associated with higher risk of short-term mortality (OR: 2.30, 95% CI: 1.52–3.45, p < 0.001), with high heterogeneity (I 2 = 89.4%). Meta-regression showed a direct correlation with male gender ( p = 0.03), hypertension ( p < 0.001), DM ( p = 0.01) and hyperlipidaemia ( p = 0.04), but no effect when considering age ( p = 0.75) and chronic pulmonary disease ( p = 0.86) as moderators. Conclusions: MetS represents a major comorbidity in about 20% of COVID-19 patients and it is associated with a 230% increased risk of short-term mortality.
【저자키워드】 COVID-19, Mortality, Prevalence, metabolic syndrome, dyslipidaemia, 【초록키워드】 Meta-analysis, review, systematic review, Comorbidity, Gender, hypertension, heterogeneity, male, Patient, Validity, Reporting, age, prognostic, correlation, COVID-19 patients, mortality risk, Analysis, Odds ratio, COVID-19 patient, higher risk, 95% CI, 95% confidence interval, increased risk, inclusion criteria, syndrome, item, chronic pulmonary disease, Final, Mantel-Haenszel, random effect, implication, was measured, performed, significantly, calculated, searched, the SARS-CoV-2, 【제목키워드】 review, metabolic, role,