SARS-CoV-2 has caused an extensive pandemic of COVID-19 all around the world. Key viral enzymes are suitable molecular targets for the development of new antivirals against SARS-CoV-2 which could represent potential treatments of the corresponding disease. With respect to its essential role in the replication of viral RNA, RNA-dependent RNA polymerase (RdRp) is one of the prime targets. HeE1-2Tyr and related derivatives were originally discovered as inhibitors of the RdRp of flaviviruses. Here, we present that these pyridobenzothiazole derivatives also significantly inhibit SARS-CoV-2 RdRp, as demonstrated using both polymerase- and cell-based antiviral assays.
All Keywords
【저자키워드】 COVID-19, SAR-CoV-2, Antiviral agents, RNA-dependent RNA polymerase, non-nucleotide inhibitor, 【초록키워드】 SARS-CoV-2, Antiviral, Replication, Antiviral assays, RdRP, Viral RNA, targets, inhibitor, disease, Potential treatment, enzyme, molecular target, derivative, polymerase, pandemic of COVID-19, caused, significantly, demonstrated, inhibit SARS-CoV-2, 【제목키워드】 SARS-CoV-2, RNA, block,
【저자키워드】 COVID-19, SAR-CoV-2, Antiviral agents, RNA-dependent RNA polymerase, non-nucleotide inhibitor, 【초록키워드】 SARS-CoV-2, Antiviral, Replication, Antiviral assays, RdRP, Viral RNA, targets, inhibitor, disease, Potential treatment, enzyme, molecular target, derivative, polymerase, pandemic of COVID-19, caused, significantly, demonstrated, inhibit SARS-CoV-2, 【제목키워드】 SARS-CoV-2, RNA, block,