Abstract The broad immunomodulatory properties of human mesenchymal stem cells (MSCs) have allowed for wide application in regenerative medicine as well as immune/inflammatory diseases, including unmatched allogeneic use. The novel coronavirus disease COVID‐19 has unleashed a pandemic in record time accompanied by an alarming mortality rate mainly due to pulmonary injury and acute respiratory distress syndrome. Because there are no effective preventive or curative therapies currently, MSC therapy (MSCT) has emerged as a possible candidate despite the lack of preclinical data of MSCs for COVID‐19. Interestingly, MSCT preclinical data specifically on immune/inflammatory disorders of the lungs were among the earliest to be reported in 2003, with the first clinical use of MSCT for graft‐vs‐host disease reported in 2004. Since these first reports, preclinical data showing beneficial effects of MSC immunomodulation have accumulated substantially, and as a consequence, over a third of MSCT clinical trials now target immune/inflammatory diseases. There is much preclinical evidence for MSCT in noninfectious—including chronic obstructive pulmonary disease, asthma, and idiopathic pulmonary fibrosis—as well as infectious bacterial immune/inflammatory lung disorders, with data generally demonstrating therapeutic effects; however, for infectious viral pulmonary conditions, the preclinical evidence is more scarce with some inconsistent outcomes. In this article, we review the mechanistic evidence for clinical use of MSCs in pulmonary immune/inflammatory disorders, and survey the ongoing clinical trials—including for COVID‐19—of MSCT for these diseases, with some perspectives and comment on MSCT for COVID‐19. Mesenchymal stem cell (MSC) therapy for immune/inflammatory pulmonary disorders. Broad immunomodulatory properties of human MSCs and MSC‐derived products allow for therapeutic use in noninfectious—including chronic obstructive pulmonary disease, asthma, and idiopathic pulmonary fibrosis—and a number of infectious immune/inflammatory lung disorders.
【저자키워드】 Asthma, COVID‐19, ARDS, Cytokine storm, clinical trial, Influenza, Mesenchymal stem cells, Idiopathic pulmonary fibrosis, COPD, bacterial pneumonia, 【초록키워드】 pandemic, therapy, Diseases, lung, MSCs, novel coronavirus disease, COVID‐19, outcomes, therapeutic, Allogeneic, pulmonary injury, mortality rate, disease, mesenchymal stem cell, regenerative, pulmonary disease, Bacterial, acute respiratory distress, Evidence, MSC, stem cell, MSC therapy, Clinical use, disorders, Perspective, syndrome, therapeutic use, lung disorders, disorder, preclinical data, Effect, effective, pulmonary conditions, lack, reported, accumulated, chronic obstructive, accompanied, curative, immunomodulatory property, 【제목키워드】 lung, COVID, Stem cell therapy, current, Gleaning,