The Coronavirus disease 2019 (COVID-19) pandemic has killed over two hundred thousand people by end of April, 2020. America and Europe top in deaths from COVID-19 whereas the numbers are lower in Africa for unclear reasons. Emerging evidence suggests the role of hyperactive immune responses characterised by high pro-inflammatory cytokines in severe cases of COVID-19 and deaths. In this perspective, we explore the possible factors that may contribute to mild inflammatory responses in some cases of COVID-19 by focusing on immune education, parasites, sex hormones and chronic diseases, as well as genetic tolerance. To build our perspective, evidence is also extracted from wild rodents due to their multi-tasking immune responses as a result of constant exposure to pathogens.
【저자키워드】 COVID-19, Inflammation, Cytokines, Immunity, parasites, genetics, mild symptoms, Hormones, 【초록키워드】 Tolerance, Coronavirus disease 2019, Europe, immune response, pandemic, Genetic, immune, death, Mild, Pathogens, rodent, Evidence, Inflammatory response, deaths, sex hormone, Chronic diseases, Factor, Perspective, Severe case, pro-inflammatory cytokine, America, contribute, build, 【제목키워드】 Sex, Mild, Inflammatory response,