Introduction Peru is among the top ten countries with the highest number of coronavirus disease 2019 (COVID-19) cases worldwide. The aim of the study was to describe the clinical features of hospitalized adult patients with COVID-19 and to determine the prognostic factors associated with in-hospital mortality. Methods We conducted a retrospective cohort study among adult patients with COVID-19 admitted to Hospital Cayetano Heredia; a tertiary care hospital in Lima, Peru. The primary outcome was in-hospital mortality. Multivariate Cox proportional hazards regression was used to identify factors independently associated with in-hospital mortality. Results A total of 369 patients (median age 59 years [IQR:49–68]; 241 (65.31%) male) were included. Most patients (68.56%) reported at least one comorbidity; more frequently: obesity (42.55%), diabetes mellitus (21.95%), and hypertension (21.68%). The median duration of symptoms prior to hospital admission was 7 days (IQR: 5–10). Reported in-hospital mortality was 49.59%. By multiple Cox regression, oxygen saturation (SaO 2 ) values of less than 90% on admission correlated with mortality, presenting 1.86 (95%CI: 1.02–3.39), 4.44 (95%CI: 2.46–8.02) and 7.74 (95%CI: 4.54–13.19) times greater risk of death for SaO 2 of 89–85%, 84–80% and <80%, respectively, when compared to patients with SaO 2 >90%. Additionally, age >60 years was associated with 1.88 times greater mortality. Conclusions Oxygen saturation below 90% on admission is a strong predictor of in-hospital mortality in patients with COVID-19. In settings with limited resources, efforts to reduce mortality in COVID-19 should focus on early identification of hypoxemia and timely access to hospital care.
【초록키워드】 COVID-19, coronavirus disease, Hospitalized, Mortality, obesity, hospital, Diabetes Mellitus, hypertension, oxygen saturation, Hypoxemia, male, Patient, age, Hospital admission, Admission, Care, clinical feature, in-hospital mortality, Prognostic factor, risk of death, retrospective cohort study, Factor, Primary outcome, median age, multivariate, effort, resources, country, reduce mortality, Result, greater, highest, identify, was used, reported, Most patient, conducted, median, less, determine, correlated, presenting, Cox proportional hazard, duration of symptom, multiple Cox regression, patients with COVID-19, 【제목키워드】 Hospitalized, Mortality, hospital, patients with COVID-19,