Viral pathogenesis studies in mice have relied on markers of severe systemic disease, rather than clinically relevant measures, to evaluate respiratory virus infection; thus confounding connections to human disease. Here, whole-body plethysmography was used to directly measure changes in pulmonary function during two respiratory viral infections. This methodology closely tracked with traditional pathogenesis metrics, distinguished both virus- and dose-specific responses, and identified long-term respiratory changes following both SARS-CoV and Influenza A Virus infection. Together, the work highlights the utility of examining respiratory function following infection in order to fully understand viral pathogenesis.
【초록키워드】 Pathogenesis, SARS-CoV, Respiratory function, viral pathogenesis, Infection, virus, Pulmonary function, Measures, respiratory virus, mice, methodology, utility, change, respiratory viral infections, marker, Metrics, connection, human disease, severe systemic disease, responses, highlight, was used, evaluate, clinically, changes in, 【제목키워드】 respiratory, New, Evaluating,