Introduction End-stage kidney disease (ESKD) patients are at a high risk for Coronavirus Disease 2019 (COVID-19). In this study, we compared characteristics and outcomes of ESKD and non-ESKD patients admitted with COVID-19 to a large safety-net hospital. Methods We evaluated 759 adults (45 with ESKD) hospitalized with COVID-19 in Spring of 2020. We examined clinical characteristics, laboratory measures and clinical outcomes. Logistic regression analyses were performed to investigate the associations between ESKD status and outcomes. Results 73% of ESKD and 47% of non-ESKD patients identified as Black (p = 0.002). ESKD patients were older and had higher rates of comorbidities. Admission ferritin was approximately 6-fold higher in ESKD patients. During hospitalization, the rise in white blood cell count, lactate dehydrogenase, ferritin and C-reactive protein, and the decrease in platelet count and serum albumin were all significantly greater in ESKD patients. The in-hospital mortality was higher for ESKD [18% vs. 10%; multivariable adjusted odds ratio 1.5 (95% CI, 0.48–4.70)], but this did not reach statistical significance. Conclusions Among hospitalized COVID-19 patients, ESKD patients had more co-morbidities and more robust inflammatory response than non-ESKD patients. The odds ratio point estimate for death was higher in ESKD patients, but the difference did not reach statistical significance.
【초록키워드】 COVID-19, Hospitalized, Hospitalization, Clinical characteristics, hospital, Comorbidities, C-reactive protein, ferritin, outcome, lactate dehydrogenase, clinical outcomes, outcomes, Characteristics, White blood cell, Patient, death, co-morbidity, Kidney disease, Platelet, serum albumin, patients, in-hospital mortality, association, Inflammatory response, Odds ratio, high risk, black, Older, adjusted odds ratio, Logistic regression analysis, hospitalized COVID-19 patients, 95% CI, spring, statistical significance, decrease, robust, multivariable, Result, greater, performed, examined, significantly, evaluated, had more, laboratory measure, with COVID-19, 【제목키워드】 COVID-19, hospital, Kidney disease, Boston, Massachusett,