Feline coronaviruses (FCoVs) are the causative agents of severe systemic disease (feline infectious peritonitis: FIP) in domestic and wild cats. FCoVs have been classified into serotypes I and II. Type I FCoV is the dominant serotype (approximately 70–90%) worldwide. Therefore, it is necessary to provide antiviral agents for type I FCoV infection. In this study, we demonstrated that itraconazole (ICZ), practically used for fungal infections in cats, inhibits the type I FCoV infection. ICZ also exhibited antiviral effect in cells after viral infection, suggesting that ICZ could potentially be used as a therapeutic.
All Keywords
【초록키워드】 viral infection, Infection, Antiviral effect, therapeutic, antiviral agent, Fungal infection, serotype, type I, severe systemic disease, dominant, Cell, inhibit, exhibited, coronavirus, demonstrated, Type, ICZ, 【제목키워드】 Coronavirus infection, type I,
【초록키워드】 viral infection, Infection, Antiviral effect, therapeutic, antiviral agent, Fungal infection, serotype, type I, severe systemic disease, dominant, Cell, inhibit, exhibited, coronavirus, demonstrated, Type, ICZ, 【제목키워드】 Coronavirus infection, type I,