Background The role of lung ultrasound (LUS) in evaluating the mid- and long-term prognoses of patients with COVID-19 pneumonia is not yet known. The objectives of this study were to evaluate associations between LUS signs at the time of screening and clinical outcomes 1 month after LUS and to assess LUS signs at the time of presentation with known risk factors for COVID-19 pneumonia. Methods This was a retrospective study of data prospectively collected 1 month after LUS screening of 447 adult patients diagnosed with COVID-19 pneumonia. Sonographic examination was performed in screening tents with the participants seated. The LUS signs (B-lines > 2, coalescent B-lines, and subpleural consolidations) were captured in six areas of each hemithorax and a LUS aeration score was calculated; in addition, the categories of disease probability based on patterns of LUS findings (high-probability, intermediate-probability, alternate, and low-probability patterns) were evaluated. The LUS signs at patients’ initial evaluation were related to the following outcomes: symptomatology, the need for hospitalization or invasive mechanical ventilation (IMV), and COVID-19-related death. Results According to the evaluations performed 1 month after LUS screening, 36 patients were hospitalised, eight of whom required intensive care unit (ICU) admission and three of whom died. The presence of coalescent B-lines was associated with the need for hospitalization ( p = 0.008). The presence of subpleural consolidations was associated with dyspnoea ( p < 0.0001), cough ( p = 0.003), the need for hospitalization ( p < 0.0001), the need for ICU admission ( p < 0.0001), and death ( p = 0.002). A higher aeration score was associated with dyspnoea ( p < 0.0001), the need for hospitalization ( p < 0.0001), the need for ICU admission ( p < 0.0001), and death ( p = 0.003). In addition, patients with a high-probability LUS pattern had a higher aeration score ( p < 0.0001) and more dyspnoea ( p = 0.024) and more often required hospitalization ( p < 0.0001) and ICU admission ( p = 0.031). Conclusions In patients with COVID-19 pneumonia, LUS signs were related to respiratory symptoms 1 month after LUS screening. Strong relationships were identified between LUS signs and the need for hospitalization and death.
【저자키워드】 COVID-19, SARS-CoV-2, Pneumonia, Lung ultrasound, 1-month outcomes, 【초록키워드】 intensive care, Hospitalization, lung, risk factor, cough, ICU, Clinical outcome, Probability, Retrospective study, Patient, ICU admission, death, disease, Admission, consolidation, Dyspnoea, association, Invasive mechanical ventilation, consolidations, participant, respiratory symptom, COVID-19-related death, hospitalised, IMV, initial, Result, performed, collected, evaluate, died, addition, evaluated, required, eight, was performed, category, Strong, diagnosed with COVID-19, patients with COVID-19, seated, subpleural, 【제목키워드】 Infection, lung, outcome, patients with SARS-CoV-2,