We tested whether pregnant and non-pregnant women differ in COVID-19 symptom profile and severity, and we extended previous investigations on hospitalized pregnant women to those who did not require hospitalization. Two female community-based cohorts (18–44 years) provided longitudinal (smartphone application, N = 1,170,315, n = 79 pregnant tested positive) and cross-sectional (web-based survey, N = 1,344,966, n = 134 pregnant tested positive) data, prospectively collected through self-participatory citizen surveillance in UK, Sweden and USA. Pregnant and non-pregnant were compared for frequencies of events, including SARS-CoV-2 testing, symptoms and hospitalization rates. Multivariable regression was used to investigate symptoms severity and comorbidity effects. Pregnant and non-pregnant women positive for SARS-CoV-2 infection were not different in syndromic severity, except for gastrointestinal symptoms. Pregnant were more likely to have received testing, despite reporting fewer symptoms. Pre-existing lung disease was most closely associated with syndromic severity in pregnant hospitalized. Heart and kidney diseases and diabetes increased risk. The most frequent symptoms among non-hospitalized women were anosmia [63% pregnant, 92% non-pregnant] and headache [72%, 62%]. Cardiopulmonary symptoms, including persistent cough [80%] and chest pain [73%], were more frequent among pregnant who were hospitalized. Consistent with observations in non-pregnant populations, lung disease and diabetes were associated with increased risk of more severe SARS-CoV-2 infection during pregnancy.
【저자키워드】 Epidemiology, Comorbidities, Respiratory signs and symptoms, 【초록키워드】 Hospitalized, Hospitalization, cross-sectional, SARS-COV-2 infection, severity, Infection, Lung disease, Comorbidity, Symptom, cough, headache, Symptoms, Anosmia, pregnant women, Pregnancy, Surveillance, SARS-CoV-2 testing, heart, female, Kidney disease, women, USA, gastrointestinal symptoms, Frequency, pregnant, chest pain, COVID-19 symptom, observation, Community-based cohort, increased risk, Multivariable regression, positive, Effects, populations, severe SARS-CoV-2, tested, was used, collected, events, provided, not different, diabete, 【제목키워드】 SARS-COV-2 infection, severity, pregnant women, Cohort, Community, syndrome,