SARS-CoV-2 can infiltrate the lower respiratory tract, resulting in severe respiratory failure and a high death rate. Normally, the airway and alveolar epithelium can be rapidly reconstituted by multipotent stem cells after episodes of infection. Here, we analyzed published RNA-seq datasets and demonstrated that cells of four different lung epithelial stem cell types express SARS-CoV-2 entry factors, including Ace2 . Thus, stem cells can be potentially infected by SARS-CoV-2, which may lead to defects in regeneration capacity partially accounting for the severity of SARS-CoV-2 infection and its consequences.
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【저자키워드】 viral infection, transcriptomics, Infection, 【초록키워드】 SARS-CoV-2, SARS-COV-2 infection, severity, severe respiratory failure, airway, Consequences, Lower respiratory tract, stem cell, cell type, death rate, Express, SARS-CoV-2 entry factors, alveolar epithelium, Cell, lung epithelial, RNA-seq dataset, resulting, analyzed, demonstrated, 【제목키워드】 COVID-19, SARS-CoV-2 entry factor, stem cell, implication, lung epithelial,
【저자키워드】 viral infection, transcriptomics, Infection, 【초록키워드】 SARS-CoV-2, SARS-COV-2 infection, severity, severe respiratory failure, airway, Consequences, Lower respiratory tract, stem cell, cell type, death rate, Express, SARS-CoV-2 entry factors, alveolar epithelium, Cell, lung epithelial, RNA-seq dataset, resulting, analyzed, demonstrated, 【제목키워드】 COVID-19, SARS-CoV-2 entry factor, stem cell, implication, lung epithelial,