The rapid increase of patients with coronavirus disease 2019 (COVID-19) has introduced major challenges to healthcare services worldwide. Therefore, fast and accurate clinical assessment of COVID-19 progression and mortality is vital for the management of COVID-19 patients. We developed an automated image-based survival prediction model, called U-survival, which combines deep learning of chest CT images with the established survival analysis methodology of an elastic-net Cox survival model. In an evaluation of 383 COVID-19 positive patients from two hospitals, the prognostic bootstrap prediction performance of U-survival was significantly higher (P < 0.0001) than those of existing laboratory and image-based reference predictors both for COVID-19 progression (maximum concordance index: 91.6% [95% confidence interval 91.5, 91.7]) and for mortality (88.7% [88.6, 88.9]), and the separation between the Kaplan–Meier survival curves of patients stratified into low- and high-risk groups was largest for U-survival (P < 3 × 10 –14 ). The results indicate that U-survival can be used to provide automated and objective prognostic predictions for the management of COVID-19 patients.
【저자키워드】 viral infection, tomography, Disease-free survival, Prognostic markers, 【초록키워드】 COVID-19, coronavirus disease, Mortality, deep learning, hospitals, Laboratory, survival, Concordance, management, Patient, automated, predictor, methodology, prognostic, group, COVID-19 patients, Analysis, COVID-19 progression, confidence interval, rapid increase, bootstrap, Chest CT image, can be used, introduced, significantly higher, stratified, COVID-19 positive patient, healthcare service, Kaplan–Meier survival curve, 【제목키워드】 Mortality, Disease progression, prognostic, patients with COVID-19,