We identified the main changes in serum metabolites associated with severe (n = 46) and mild (n = 19) COVID-19 patients by gas chromatography coupled to mass spectrometry. The modified metabolic profiles were associated to an altered amino acid catabolism in hypoxic conditions. Noteworthy, three α-hydroxyl acids of amino acid origin increased with disease severity and correlated with altered oxygen saturation levels and clinical markers of lung damage. We hypothesize that the enzymatic conversion of α-keto-acids to α- hydroxyl-acids helps to maintain NAD recycling in patients with altered oxygen levels, highlighting the potential relevance of amino acid supplementation during SARS-CoV-2 infection.
All Keywords
【저자키워드】 viral infection, metabolomics, hypoxia, 【초록키워드】 SARS-COV-2 infection, disease severity, oxygen saturation, serum, Patient, Mild, metabolite, Amino acid, COVID-19 patient, lung damage, profile, help, hypoxic conditions, oxygen levels, changes in, correlated, maintain, highlighting, clinical marker, 【제목키워드】 Analysis, COVID-19 patient, amino acid metabolism, reveal, oxygen homeostasis,
【저자키워드】 viral infection, metabolomics, hypoxia, 【초록키워드】 SARS-COV-2 infection, disease severity, oxygen saturation, serum, Patient, Mild, metabolite, Amino acid, COVID-19 patient, lung damage, profile, help, hypoxic conditions, oxygen levels, changes in, correlated, maintain, highlighting, clinical marker, 【제목키워드】 Analysis, COVID-19 patient, amino acid metabolism, reveal, oxygen homeostasis,