The ongoing coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is posing a great threat to the global economy and public health security. Together with the acknowledged angiotensin-converting enzyme 2, glucose-regulated protein 78, transferrin receptor, AXL, kidney injury molecule-1, and neuropilin 1 are also identified as potential receptors to mediate SARS-CoV-2 infection. Therefore, how to inhibit or delay the binding of SARS-CoV-2 with the abovementioned receptors is a key step for the prevention and treatment of COVID-19. As the third gasotransmitter, hydrogen sulfide (H 2 S) plays an important role in many physiological and pathophysiological processes. Recently, survivors were reported to have significantly higher H 2 S levels in COVID-19 patients, and mortality was significantly greater among patients with decreased H 2 S levels. Considering that the beneficial role of H 2 S against COVID-19 and COVID-19-induced comorbidities and multiorgan damage has been well-examined and reported in some excellent reviews, this review will discuss the recent findings on the potential receptors of SARS-CoV-2 and how H 2 S modulates the above receptors, in turn blocking SARS-CoV-2 entry into host cells.
【초록키워드】 COVID-19, Treatment, coronavirus disease, public health, SARS-CoV-2, coronavirus, pandemic, Mortality, SARS-COV-2 infection, Comorbidity, angiotensin-converting enzyme 2, Kidney injury, Protein, Transferrin, Patient, receptors, receptor, COVID-19 patients, binding, Multiorgan, physiological, Hydrogen sulfide, host cells, acute respiratory syndrome, SARS-CoV-2 entry, survivor, greater, caused, significantly, reported, inhibit, modulate, significantly higher, turn, recent finding, pathophysiological, 【제목키워드】 SARS-CoV-2, surface, hydrogen, blocking, role, Potential,