Abstract The coronavirus infectious disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains a world health concern and can cause severe disease and high mortality in susceptible groups. While vaccines offer a chance to treat disease, prophylactic and anti-viral treatments are still of vital importance, especially in context of the mutative ability of this group of viruses. Therefore, it is essential to elucidate the molecular mechanisms of viral entry, innate sensing and immune evasion of SARS-CoV-2, which control the triggers of the subsequent excessive inflammatory response. Viral evasion strategies directly target anti-viral immunity, counteracting host restriction factors and hijacking signalling pathways to interfere with interferon production. In Part I of this review, we examine SARS-CoV-2 viral entry and the described immune evasion mechanisms to provide a perspective on how the failure in initial viral sensing by infected cells can lead to immune dysregulation causing fatal COVID-19, discussed in Part II. Graphical Abstract Graphical Abstract
【저자키워드】 COVID-19, SARS-CoV-2, interferon, host response, viral entry, viral evasion, 【초록키워드】 viruses, Vaccine, coronavirus, pandemic, Infectious disease, Prophylactic, molecular mechanism, excessive inflammatory response, immune evasion, Health, pathway, disease, mechanism, severe disease, Trigger, immune dysregulation, acute respiratory syndrome, Anti-viral treatment, Perspective, high mortality, treat, fatal COVID-19, infected cell, while, offer, Anti-viral immunity, Host, susceptible, initial, SARS-CoV-2 viral, described, caused, subsequent, interfere, groups, restriction factor, Part, 【제목키워드】 immunology, Innate, Part,