Abstract SARS-CoV-2, the etiological agent of COVID-19, triggers an adaptive immunity in the infected host that results in the production of virus-specific antibodies and T cells. While kinetic and quantitative aspects of antibodies have been analyzed in large patient cohorts, similar information about SARS-CoV-2-specific T cells are scarce. We summarize in this review the available knowledge of quantitative and temporal features of the SARS-CoV-2 T cell response. Currently, most of the data derived only from the analysis of the circulatory compartment. Despite this limitation, early appearance, multi-specificity and functionality of SARS-CoV-2-specific T cells are associated with accelerated viral clearance and with protection from severe COVID-19.
【초록키워드】 COVID-19, SARS-CoV-2, adaptive, severe COVID-19, Immunity, antibody, T cells, knowledge, viral clearance, information, Quantitative, T cell response, Analysis, Trigger, kinetic, etiological agent, while, Host, feature, analyzed, accelerated, large patient cohorts, SARS-CoV-2-specific T cell, the SARS-CoV-2, 【제목키워드】 Quantitative, T cell response, kinetic, protective role,