Background Studies have reported COVID-19 as an independent risk factor for arterial thromboemboli. Methods From a cross-sectional sample, we determined the incidence and location of arterial thromboemboli (myocardial infarction, ischemic stroke, peripheral artery), stratified by COVID-19 status, in the RECOVER database, which included data on patients at 45 United States medical centers in 22 states. Epidemiological factors, clinical characteristics and outcomes were collected through a combination of individual chart review and automatic electronic query and recorded in REDCap®. We investigated the association of baseline comorbidities on the development of arterial thromboemboli and analyzed results based on the presence or absence of concomitant COVID-19 infection, testing this association with Chi-squared. We also described use of anticoagulants and statins. Results Data were collected on 26,974 patients, of which 13,803 (51.17%) tested positive for COVID-19. Incidence of arterial thromboemboli during hospitalization was 0.13% in patients who tested positive for COVID-19 and 0.19% in patients who tested negative. Arterial thromboemboli tended to be more common in extremities than in core organs (heart, kidney, lung, liver) in patients with COVID-19, odds ratio 2.04 (95% CI 0.707 – 5.85). Patients with COVID-19 were less likely to develop an arterial thrombus when on baseline statin medication ( p =0.014). Presence of metabolic syndrome predicted presence of core arterial thrombus ( p =0.001) and extremity arterial thrombus ( p =0.010) in those with COVID-19. Arterial thromboemboli were less common in patients with COVID-19 than in those who tested negative for COVID-19. Conclusions Presence of a composite metabolic syndrome profile may be associated with arterial clot formation in patients with COVID-19 infection.
【초록키워드】 COVID-19, Hospitalization, Clinical characteristics, cross-sectional, stroke, Infection, lung, Comorbidity, outcome, database, kidney, COVID-19 infection, Patient, Factors, Thrombus, incidence, Myocardial infarction, medication, liver, patients, association, Anticoagulant, Combination, Odds ratio, 95% CI, syndrome, independent risk factor, positive, organ, arterial, Result, tested, described, predicted, analyzed, collected, develop, reported, United State, investigated, less, absence, recorded, stratified, baseline, patients with COVID-19, Presence, with COVID-19, 【제목키워드】 Characteristics, patients with COVID-19,