Highlights • hPSC-derived cells/organoids are emerging tools to study the tropism of SARS-CoV-2 infection. • hPSC-derived cells/organoids provide crucial tools to examine cellular response to SARS-CoV-2 infection. • hPSC-derived cells/organoids can be applied to screen for drug candidates for COVID-19 patients. The coronavirus disease 2019 (COVID-19) global pandemic caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected over 200 countries and territories worldwide and resulted in more than 2.5 million deaths. In a pressing search for treatments and vaccines, research models based on human stem cells are emerging as crucial tools to investigate SARS-CoV-2 infection mechanisms and cellular responses across different tissues. Here, we provide an overview of the variety of human pluripotent stem cell-based platforms adopted in SARS-CoV-2 research, comprising monolayer cultures and organoids, which model the multitude of affected tissues in vitro . We highlight the strengths of these platforms, including their application to assess both the susceptible cell types and the pathogenesis of SARS-CoV-2. We describe their use to identify drug candidates for further investigation in addition to discussing their limitations in fully recapitulating COVID-19 pathophysiology. Overall, stem cell models are facilitating the understanding of SARS-CoV-2 and prove to be versatile platforms for studying infections.
【저자키워드】 COVID-19, stem cells, SARS-CoV-2, Drug discovery, Personalized medicine, Organoid, (6 MAX), 【초록키워드】 Treatment, coronavirus disease, coronavirus, Vaccines, SARS-COV-2 infection, Infection, in vitro, global pandemic, infections, Culture, pathophysiology, Research, organoids, platform, mechanism, COVID-19 patients, cellular response, deaths, stem cell, acute respiratory syndrome, tissue, tissues, SARS-CoV-2 research, limitation, drug candidate, pathogenesis of SARS-CoV-2, country, Cell, highlight, identify, affected, caused, addition, variety, adopted, susceptible cell, tropism of SARS-CoV-2, 【제목키워드】 SARS-COV-2 infection, Human, platform, Cell,