Coronavirus disease 19 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is associated with various clinical manifestations, including skin lesions. In particular, during the COVID-19 pandemic lock-down period numerous chilblain-like lesions, mainly located on the feet, were observed in adolescents. The latter were often asymptomatic or associated with very mild respiratory symptoms. Here, we report three cases of acral nodular lesions in SARS-CoV-2 swab-negative adolescents with histological findings of chronic immune-mediated inflammation and immunohistochemical evidence of SARS-CoV-2 spike glycoproteins in endothelial cells and eccrine sweat glands. In one of these cases, the virus presence was confirmed by electron microscopy.
【저자키워드】 SARS-CoV-2, skin, chilblains, granuloma annulare, 【초록키워드】 COVID-19, coronavirus, COVID-19 pandemic, virus, clinical manifestations, Asymptomatic, SARS-CoV-2 spike glycoprotein, Microscopy, coronavirus disease 19, Endothelial cell, Evidence, skin lesions, lesion, acute respiratory syndrome, lesions, mild respiratory symptoms, caused, histological, eccrine sweat glands, immune-mediated inflammation, lock-down period, 【제목키워드】 COVID-19, lesion,