Background Due to their health condition, patients with neuromuscular diseases (NMD) are at greater risk of developing serious complications with COVID-19. The objective of this study was to analyze the prevalence of COVID-19 among NMD patients and the risk factors for its impact and severity during the first wave of the pandemic. Clinical data were collected from NMD-COVID-19 patients, between March 25, 2020 and May 11, 2020 in an anonymous survey carried out by expert physicians from the French Health Care Network Filnemus. Results Physicians reported 84 patients, including: 34 with myasthenia gravis, 27 with myopathy and 23 with neuropathy. COVID-19 had no effect on NMD for 48 (58%) patients and 48 (58%) patients developed low COVID-19 severity. COVID-19 caused the death of 9 (11%) NMD patients. Diabetic patients were at greater risk of dying. Patients with diabetes, hypertension or severe forms of NMD had a higher risk of developing a moderate or severe form of COVID-19. In our cohort, corticosteroids and other immunosuppressants were not significantly associated with higher COVID-19 severity for acquired NMD. Conclusion During this period, a small percentage of French NMD patients was affected by COVID-19 compared to the general French population and COVID-19 had a limited short-term effect on them. Diabetes, hypertension and a severe degree of NMD were identified as risk factors of unfavorable outcome following COVID-19. Conversely, in our cohort of patients with acquired NMD, corticosteroids or other immunosuppressants did not appear to be risk factors for more severe COVID-19.
【저자키워드】 COVID-19, Prognosis, risk factor, neuromuscular diseases, 【초록키워드】 Corticosteroid, pandemic, severe COVID-19, severity, COVID-19 severity, risk, diabetes, outcome, hypertension, Cohort, clinical, Patient, death, network, First wave, moderate, patients, Immunosuppressant, higher risk, French, physician, health condition, neuromuscular disease, serious complication, diabetic patient, Result, greater, affected, collected, caused, carried, significantly, reported, form, had no, cohort of patient, prevalence of COVID-19, with COVID-19, 【제목키워드】 cross-sectional, multicenter, French, neuromuscular disease,