Acute lung injury (ALI), an increasingly devastating human disorder, is characterized by a multitude of lung changes arising from a wide variety of lung injuries. Viral infection is the main cause of morbidity and mortality in ALI and acute respiratory distress syndrome (ARDS) patients. In particular, influenza virus, coronavirus, and other respiratory viruses circulate in nature in various animal species and can cause severe and rapidly spread human infections. Although scientific advancements have allowed for rapid progress to be made to understand the pathogenesis and develop therapeutics after each viral pandemic, few effective methods to treat virus-induced ALI have been described. Recently, stem cell therapy has been widely used in the treatment of various diseases, including ALI. In this review, we detail the present stem cell-based therapeutics for lung injury caused by influenza virus and the outlook for the future state of stem cell therapy to deal with emerging influenza and coronaviruses.
【저자키워드】 Coronaviruses, Mesenchymal stem cells, Influenza virus, acute lung injury, Stem cell therapy, Lung stem/progenitor cells, 【초록키워드】 Treatment, ARDS, coronavirus, pandemic, Diseases, Pathogenesis, Influenza, Infection, lung, Lung injury, Spread, morbidity and mortality, change, patients, acute respiratory distress, lung injuries, rapid progress, syndrome, treat, human infections, effective, described, develop, caused, characterized, arising, variety, increasingly, other respiratory virus, human disorder, 【제목키워드】 virus, stem cell, approach, treatment of influenza,