Abstract Search of new strategies for the inhibition of respiratory viruses is one of the urgent health challenges worldwide, as most of the current therapeutic agents and treatments are inefficient. Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has caused a pandemic and has taken lives of approximately two million people to date. Even though various vaccines are currently under development, virus, and especially its spike glycoprotein can mutate, which highlights a need for a broad‐spectrum inhibitor. In this work, inhibition of SARS‐CoV‐2 by graphene platforms with precise dual sulfate/alkyl functionalities is investigated. A series of graphene derivatives with different lengths of aliphatic chains is synthesized and is investigated for their ability to inhibit SARS‐CoV‐2 and feline coronavirus. Graphene derivatives with long alkyl chains (>C9) inhibit coronavirus replication by virtue of disrupting viral envelope. The ability of these graphene platforms to rupture viruses is visualized by atomic force microscopy and cryogenic electron microscopy. A large concentration window (10 to 100‐fold) where graphene platforms display strongly antiviral activity against native SARS‐CoV‐2 without significant toxicity against human cells is found. In this concentration range, the synthesized graphene platforms inhibit the infection of enveloped viruses efficiently, opening new therapeutic and metaphylactic avenues against SARS‐CoV‐2. Present work shows that both electrostatic and hydrophobic interactions play a key role at the graphene/coronavirus interfaces and such materials can efficiently protect cells from coronavirus infections. While electrostatic interactions are responsible for the capturing of viruses, hydrophobic long alkyl chains can disrupt the envelop of the captured virions via hydrophobic interactions leading to a dual effect.
【저자키워드】 Graphene, graphene‐based polyglycerol sulfates, SARS‐CoV‐2 inhibitor, virucidality, 【초록키워드】 Treatment, viruses, Vaccine, coronavirus, pandemic, spike glycoprotein, Infection, Toxicity, antiviral activity, virus, SARS‐CoV‐2, Coronavirus infections, Health, respiratory virus, Microscopy, therapeutic, therapeutic agent, inhibitor, platform, Concentration, Coronavirus replication, acute respiratory syndrome, present, hydrophobic, virion, derivative, rupture, while, viral envelope, human cell, electrostatic interaction, Cell, highlight, PROTECT, responsible, caused, investigated, inhibit, atomic, electrostatic, mutate, inefficient, disrupt, disrupting, aliphatic chain, hydrophobic interaction, 【제목키워드】 SARS‐CoV‐2, Strong, Sheet,