We report the case of a 48-year-old man followed since 2013 for primary antiphospholipid syndrome (APLS) revealed by venous thromboembolism in the presence of antiphospholipid antibodies (APL-Abs, anticardiolipin and anti-β-2-glycoprotein-1), who decompensated in the course of coronavirus disease (COVID-19). Despite efficient anticoagulation, he suffered bilateral adrenal glands hemorrhage and limb arterial ischemia. The tropism of severe acute respiratory syndrome coronavirus-2 for endothelium can lead to microangiopathy and increased risk for thrombosis. If APL-Abs positivity can be an epiphenomenon under inflammatory and prothrombotic conditions, COVID-19 was herein responsible for disseminated thrombosis and a threat of catastrophic APLS, despite efficient anticoagulation.
【저자키워드】 COVID-19, thrombosis, Hydroxychloroquine, Infection, Antiphospholipid syndrome, 【초록키워드】 coronavirus disease, anticoagulation, antibody, Venous Thromboembolism, Endothelium, Coronavirus-2, Ischemia, Inflammatory, hemorrhage, acute respiratory syndrome, increased risk, syndrome, prothrombotic, limb, catastrophic, Course, responsible, suffered, conditions, 【제목키워드】 flare,