Background Cancer patients infected with severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) have an increased risk of mortality. Here, we investigated predictive factors for coronavirus disease 2019 (COVID-19) associated mortality in patients with neoplastic diseases treated throughout Austria. Methods In this multicentric nationwide cohort study, data on patients with active or previous malignant diseases and SARS-CoV‑2 infections diagnosed between 13 March 2020 and 06 April 2021 were collected. Collected data included the stage of the malignant disease and outcome parameters 30 days after the diagnosis of SARS-CoV‑2 infection. Results The cohort consisted of 230 individuals of which 75 (32.6%) patients were diagnosed with hematologic malignancies and 155 (67.4%) with solid tumors. At a median follow-up of 31 days after COVID-19 diagnosis, 38 (16.5%) patients had died due to COVID-19. Compared to survivors, patients who died were older (62.4 vs. 71.4 years, p < 0.001) and had a higher ECOG performance status (0.7 vs. 2.43, p < 0.001). Furthermore, higher neutrophil counts (64.9% vs. 73.8%, p = 0.03), lower lymphocyte counts (21.4% vs. 14%, p = 0.006) and lower albumin levels (32.5 g/l vs. 21.6 g/l, p < 0.001) were observed to be independent risk factors for adverse outcomes. No association between mortality and systemic antineoplastic therapy was found ( p > 0.05). In 60.6% of the patients, therapy was postponed due to quarantine requirements or hospital admission. Conclusion Mortality of Austrian cancer patients infected with SARS-CoV‑2 is comparable to that of other countries. Furthermore, risk factors associated with higher mortality were evident and similar to the general population. Treatment delays were frequently observed.
【저자키워드】 COVID-19, pandemic, Risk factors, cancer treatment, SARS-CoV‑2 infection, 【초록키워드】 coronavirus disease, SARS-CoV-2, coronavirus, therapy, Mortality, quarantine, Diagnosis, outcome, risk factor, adverse outcomes, cohort study, Lymphocyte count, Cohort, Survivors, Patient, COVID-19 diagnosis, Hospital admission, Follow-up, General population, disease, patients, association, SARS-CoV‑2, Hematologic malignancy, solid tumors, performance status, cancer patient, Predictive, acute respiratory syndrome, Older, Factor, increased risk, neutrophil count, independent risk factor, malignant disease, parameter, SARS-CoV‑2 infection, Result, collected, died, investigated, diagnosed, treated, comparable, albumin level, 【제목키워드】 Treatment, Mortality, cancer patient, finding,